WP 6: Tailored vaccine development, testing and validation

Objectives:

1) Benchmarking the use of deep RNA sequencing as method to assess the effects of vaccine chassis on target animals.

2) Immunological evaluation of M. hyopneumoniae vaccine prepared in serum-free medium in pigs.

3) Immunological evaluation of the inactivated vector vaccine against M. hyopneumoniae in pigs.

4) Immunological evaluation of the live vector vaccine against M. hyopneumoniae in pigs.

5) Immunological evaluation of the novel vector vaccine against M. bovis in cows